NSE (Native Storage Extension = saving RAM) now usable for S/4, BW/4&HANA native, see SAP Note 2799997-FAQ: SAP HANA (NSE)
For app specific info / restrictions pls see SAP Notes 2816823 (S/4, BS), 2798428 (S/4 FI), 2347382 (BW/4:
NSE for DTO supported starting BW/4HANA 2.0 SP04)